The Gross Domestic Product (GDP) is a significant indicator of its economic well–being. As per the latest data, the Harlingen-Brownsville Metropolitan Statistical Area (MSA) had a GDP of 10,741,407 million dollars in the year 2021. This value represents the market worth of all final goods and services produced within the metropolitan area.

The GDP is an important indicator as it reflects the economic output and productivity of the region. A high GDP indicates a strong economy with a high output of goods and services, which can attract businesses and investors, leading to job creation and economic growth.

The main industrial sectors in Harlingen, Texas, are:
Healthcare: Three of the top 10 employers in Harlingen are in the medical field. The Regional Academic Health Center, a branch of the University of Texas-San Antonio Health Science Center; the South Texas Veterans Administration Health Care Center at Harlingen; and the physician-owned Harlingen Medical Center are all important elements.
Telecommunications: Tapping into Harlingen’s talented and bilingual workforce are United Healthcare, Dish Network, Qualfon, Spectrum, and Advanced Call Center Technologies.
Manufacturing: Dozens of Tier I, II, and III manufacturers and suppliers take advantage of Harlingen’s central location in the Rio Grande Valley, close proximity to Northern Mexico, and access to major highways and intermodal, air, and water transportation outlets.
Aerospace and Logistics: These are the other two main sectors of Harlingen.
Education: Harlingen’s top employers are in education. Texas State Technical College in Harlingen is known for its technology programs. Agriculture: Agriculture is still very important to the Harlingen economy.