The Gross Domestic Product (GDP) for Brownsville-Harlingen, Texas, has shown significant growth over the years. According to the U.S. Bureau of Economic Analysis, the GDP of Brownsville-Harlingen MSA in 2021 was 13,225,538 million dollars, its highest historical record since 2001.

This economic indicator reflects the overall economic health of the region, demonstrating the value of all goods and services produced over a specific time period. The growth in GDP indicates a thriving and growing economy in Brownsville, Texas.

The main industrial sectors in Brownsville are:
Manufacturing: Brownsville is home to several manufacturing companies, including Keppel AmFELS, which builds ships and offshore structures, and National Electric Coil, which produces electrical components for the automotive and aerospace industries.
Logistics and Transportation: Brownsville is a major logistics and transportation hub, thanks to its strategic location on the Gulf Coast and its proximity to the Mexico-US border1. The city is home to the Port of Brownsville, one of the busiest ports in the United States.
Food Processing: Brownsville is a major center for food processing, thanks to its proximity to the Mexico-US border and its large agricultural industry. The city is home to a number of food processing companies.
Energy: Brownsville is home to a number of oil and gas companies, as well as a number of renewable energy companies. The city is also located near the Eagle Ford Shale Formation, one of the largest oil and gas reserves in the United States.
Health Care Services: Health care services are among the industries that stand out as highly concentrated and unique to the regional economy. Aerospace Component Manufacturing, Research & Development, Spaceport Certification, Robotics & Technology, Microgrid Renewables, Energy Storage, Automotive Assembly & Parts Manufacturing.